effect of a combination of omeprazole plus sustained release baclofen versus omeprazole alone on symptoms of patients with gastroesophageal reflux disease (gerd)
نویسندگان
چکیده
previous studies have reported the efficacy of baclofen in the treatment of gastroesophageal reflux diseases (gerd). the objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained release baclofen (sr baclofen) vs omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of gerd. a prospective, double blind, placebo controlled trial included 50 patients with diagnosis of gerd have been done. patients were randomly selected to receive either sr baclofen or a placebo in addition to omeprazole 20 mg/d for a period of 2 weeks. patients were questioned regarding heartburn, regurgitation, chest pain and hoarseness at the base line and after 2 weeks. all patients tolerated the medications and no patients failed to complete the study due to adverse drug reactions. a total of 53 patients completed the study, 25 in sr baclofen and 28 in placebo group. after 2 weeks, 1 patient (4%) in sr baclofen group reported heartburn and regurgitation. however 13(46.4%) and 15 (53.6%) of patients in the placebo group had heartburn and regurgitation respectively. the analysis of the data shows that there is a significant difference between the two groups in heartburn and regurgitation (p < 0.0001, p < 0.0001 respectively). statistical analysis revealed a significant difference in two groups regarding total gerd score (p <0.0001). the results of the present study suggest that a combination of sr baclofen and omeprazole may be a more effective treatment for heartburn and regurgitation than omeprazole alone
منابع مشابه
Effect of a Combination of Omeprazole Plus Sustained Release Baclofen Versus Omeprazole Alone on Symptoms of Patients with Gastroesophageal Reflux Disease (GERD)
Previous studies have reported the efficacy of baclofen in the treatment of Gastroesophageal Reflux Diseases (GERD). The objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained Release baclofen (SR baclofen) vs omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of GERD. A prospective, double blind, place...
متن کاملEffect of a Combination of Omeprazole Plus Sustained Release Baclofen Versus Omeprazole Alone on Symptoms of Patients with Gastroesophageal Reflux Disease (GERD)
Previous studies have reported the efficacy of baclofen in the treatment of Gastroesophageal Reflux Diseases (GERD). The objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained Release baclofen (SR baclofen) vs omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of GERD. A prospective, double blind, place...
متن کاملEffect of a Combination of Omeprazole Plus Sustained Release Baclofen Versus Omeprazole Alone on Symptoms of Patients with Gastroesophageal Reflux Disease (GERD)
Previous studies have reported the efficacy of baclofen in the treatment of Gastroesophageal Reflux Diseases (GERD). The objective of present study is to evaluate the effect of co-administration of omeprazole 20 mg/d plus sustained Release baclofen (SR baclofen) vs. omeprazole 20 mg/d plus placebo on alleviation of symptoms in patients with a diagnosis of GERD. A prospective, double blind, plac...
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Background: Effect of Ramadan fasting on gastroesophageal reflux disease (GERD) is unknown and limited studies have been conducted in this regard. Nutritional, physiological, psychological and behavioral changes in fasting individuals during Ramadan may affect GERD. The present study aimed to evaluate the effects of these changes on GERD symptoms with more meticulous method. Materials and Metho...
متن کاملGastroesophageal Reflux Disease (GERD)
Diagnosis History. If classic symptoms of heartburn and acid regurgitation dominate a patient’s history, then they can help establish the diagnosis of GERD with sufficiently high specificity, although sensitivity remains low compared to 24-hour pH monitoring. The presence of atypical symptoms (Table 1), although common, cannot sufficiently support the clinical diagnosis of GERD [B*]. Testing....
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۳، شماره ۴، صفحات ۱۲۲۱-۱۲۲۶
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